I'm hoping I like Game of Thrones more than I liked Wolfe's Book of the New Sun, the other uber-popular, "life-changing" fantasy book I recently read. I didn't dislike Wolfe's book, I actually thought it was pretty good, but it didn't blow my socks off like I thought it would.
The best single-volume fantasy I've ever read is still J.M. McDermott's The Last Dragon (absolutely brilliant in every way), and the best series is a tie between Michael Moorcock's Elric Saga, and Stephen Kings The Dark Tower.