Gretchen Speck-Horowitz, same actress and character from episode 2 of Wonderfalls, just picked up the wrong insulin at the pharmacy. She even quotes her line from that episode, "I lost the hyphen, kept the ring." Which means that Wonderfalls and Hannibal take place in the same universe, which means that it's entirely possible Graham will start having conversations with wax lions.
Also, I'm going to be sad if Gretchen Speck-Horowitz is killed and made into mushrooms when Jaye went to all the trouble of fixing her life by breaking up her marriage.